期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
卷 17, 期 15, 页码 4493-4513出版社
IVYSPRING INT PUBL
DOI: 10.7150/ijbs.66181
关键词
LncRNAs; Lipid metabolism; Ferroptosis; Cancer
资金
- National Natural Science Foundation of China [81802785, 82100490]
- Hunan Provincial Natural Science Foundation of China [2020JJ5382, 2020JJ5381]
- Scientific Research Project of Hunan Provincial Health Commission [20200763]
- Basic Research Project of the Changsha Science and Technology Bureau [kq2004127]
The review summarizes the role of long noncoding RNAs in regulating aberrant lipid metabolism and ferroptosis in cancer, as well as how lipid metabolism can influence the expression of lncRNAs, and discusses the mechanisms by which lncRNAs affect ferroptosis. Understanding the interactions between lncRNAs, lipid metabolism, and ferroptosis could lead to the development of novel strategies for precise cancer treatment in the future.
Abnormal lipid metabolism including synthesis, uptake, modification, degradation and transport has been considered a hallmark of malignant tumors and contributes to the supply of substances and energy for rapid cell growth. Meanwhile, abnormal lipid metabolism is also associated with lipid peroxidation, which plays an important role in a newly discovered type of regulated cell death termed ferroptosis. Long noncoding RNAs (lncRNAs) have been proven to be associated with the occurrence and progression of cancer. Growing evidence indicates that lncRNAs are key regulators of abnormal lipid metabolism and ferroptosis in cancer. In this review, we mainly summarized the mechanism by which lncRNAs regulate aberrant lipid metabolism in cancer, illustrated that lipid metabolism can also influence the expression of lncRNAs, and discussed the mechanism by which lncRNAs affect ferroptosis. A comprehensive understanding of the interactions between lncRNAs, lipid metabolism and ferroptosis could help us to develop novel strategies for precise cancer treatment in the future.
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