期刊
HETEROCYCLES
卷 103, 期 2, 页码 839-861出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.3987/COM-20-S(K)52
关键词
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资金
- JSPS KAKENHI Grunt [JP19K07006]
- Takahashi Industrial and Economic Research Foundation [10-003-181]
- Professor Y. Uozumi's JST-ACCEL program [JPMJAC1401]
The immobilized fluorous-tagged proline catalyst, with acidic sulfonamide groups bearing multifluorous tags at the carboxy position, proved to be more effective in achieving high stereoselectivity than introducing bulky substituents on the proline backbone. The Teflon (R)-immobilized proline catalyst could be recovered and reused at least five times while maintaining high levels of catalytic activity and stereoselectivity.
An immobilized fluorous-tagged proline catalyst and its application as a recycling system in highly stereoselective asymmetric aldol reactions are described. The introduction of acidic sulfonamide groups bearing multifluorous tags at the carboxy position proved to be more effective than the introduction of bulky substituents on the proline backbone to achieve high stereoselectivity. The Teflon (R)-immobilized proline catalyst could be recovered and reused at least five times while maintaining high levels of catalytic activity and stereoselectivity.
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