期刊
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
卷 15, 期 1, 页码 1232-1243出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/16583655.2021.2024998
关键词
Capsicum frutescens; Enzymatic antioxidant system; Non-enzymatic antioxidants; Hypoglycemic activity; Streptozotocin (STZ) induced Diabetes
The study found that the acetone extract of Capsicum frutescens fruits can significantly lower blood glucose levels, reduce LDL cholesterol, and increase HDL cholesterol, demonstrating anti-diabetic properties in diabetic-induced Wistar rats.
According to our insight, it is the first investigation based on a literature review to establish the oxidative stress defense and hypoglycemic effects of Capsicum frutescens fruits. The anti-hyperglycemic effect of acetone extract of the fruits of C. frutescens (CFA) was imposed at 250mg/kg and 500mg/kg for 21 days in diabetic-induced Wistar rats. The rats were divided into five groups as control, diabetic, diabetic receiving glibenclamide, and two diabetic receiving CFA-treatment groups. Beginning on the 4th day and up to the 21st day of therapy, CFA at 250mg/kg and 500mg/kg demonstrated a substantial decrease in Blood Glucose Levels (BGL). CFA at 500mg/kg led to a considerable decrease in Low-Density Lipoprotein (LDL) cholesterol and a substantial increase in High-Density Lipoprotein (HDL) cholesterol, showing that CFA possesses anti-diabetic properties. Histopathological examinations reveal hepatic, pancreatic, and renal regularization. As a result, the current study clearly demonstrated more important antidiabetic activity of CFA extracts.
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