Biocompatible perovskite quantum dots with superior water resistance enable long-term monitoring of the H2S level in vivo

The application of perovskite quantum dots (PQDs) in biomedical fields such as bioimaging and biosensing has been limited owing to their instability in the physiological environment. Herein, PQDs are innovatively encapsulated into nano-micelles composed of a polyethylene glycol-polycaprolactone (PEG-PCL) block copolymer, which allows the preparation of biocompatible PQDs (bio-PQDs) with excellent water resistance. Due to the benefits of extraordinary water resistance and biocompatibility, these bio-PQDs are capable of real-time and long-term quantitatively monitoring the H2S level in living cells as well as in zebrafish.

Automated summary

Encapsulating perovskite quantum dots into nano-micelles composed of a polyethylene glycol-polycaprolactone block copolymer allows the preparation of biocompatible PQDs with excellent water resistance, enabling real-time and long-term quantitative monitoring of hydrogen sulfide levels in living cells and zebrafish.