期刊
ANIMAL NUTRITION
卷 7, 期 4, 页码 1283-1295出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.aninu.2021.09.009
关键词
Intermittent fasting; Gut microbiota; Obesity; Akkermansia muciniphila
资金
- Key Scitech innovation team of Shaanxi province [2017KCT-24]
- National Nature Science Foundation of China [U1804106]
- Natural Science Foundation of China [81860762]
- Qinghai Fundamental Scientific and Technological Research Plan [2018-ZJ-721]
- Scientific Research Guiding Plan Topic of Qinghai Hygiene Department [2018-wjzdx-131]
This paper focuses on the interaction between intermittent fasting and gut microbiota, highlighting the potential positive effects on host energy metabolism. It also discusses a potential recommended strain (Akkermansia muciniphila) and a regulatory pathway (circadian rhythm) for gut microbiota in improving host energy metabolism in IF.
Historically, intermittent fasting (IF) has been considered as an effective strategy for controlling the weight of athletes before competition. Along with excellent insight into its application in various spaces by numerous studies, increasing IF-mediated positive effects have been reported, including anti-aging, neuroprotection, especially obesity control. Recently, the gut microbiota has been considered as an essential manipulator for host energy metabolism and its structure has been reported to be sensitive to dietary structure and habits, indicating that there is a potential and strong association between IF and gut microbiota. In this paper, we focus on the crosstalk between these symbionts and energy metabolism during IF which hold the promise to optimize host energy metabolism at various physical positions, including adipose tissue, liver and intestines, and further improve milieu internal homeostasis. Moreover, this paper also discusses the positive function of a potential recommendatory strain (Akkermansia muciniphila) based on the observational data for IF-mediated alternated pattern of gut microbiota and a hopefully regulatory pathway (circadian rhythm) for gut microbiota in IF-involved improvement on host energy metabolism. Finally, this review addresses the limitation and perspective originating from these studies, such as the association with tissue-specific bio-clock and single strain research, which may continuously reveal novel viewpoints and mechanisms to understand the energy metabolism and develop new strategies for treating obesity, diabetes, and metabolic disorders. (c) 2021 Chinese Association of Animal Science and Veterinary Medicine. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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