期刊
ENVIRONMENT INTERNATIONAL
卷 108, 期 -, 页码 63-74出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2017.07.023
关键词
Fruits; Risk assessment; Pesticide; Prioritization; Risk/benefits balance; Vegetables
资金
- Ministere de la Sante et des Services Sociaux du Quebec
Pesticide residues in food is a public health concern. This study aimed to evaluate health risk and benefit associated with chronic consumption of fruits and vegetables (F & V) containing residual pesticides in the province of Quebec, Canada. Based on a representative sample of Quebecers (n = 4727, aged 1-79) enrolled in the Canadian nutrition survey, population's mean chronic dietary exposure through consumption of F & V was evaluated for 169 different pesticide active ingredients (PAI), including 135 for which toxicological reference values (TRV) were available in the literature. Total lifetime cancer risk was estimated to be 3.3 x 10(-4) considering the 28 substances for which an oral slope factor was also available. Non-cancer risk quotients greater than 1 were obtained at the 95th percentile of children's exposure for 10 of the 135 PAIs, and considering the most severe pesticide-specific TRV. Dithiocarbamates and imazalil are the authorized PAI that contribute the most to cancer and non cancer risk; they are therefore identified as priority PAI. For each estimated case of cancer triggered by PAI exposure, at least 88 cases were deemed prevented by the consumed F & V, based on the population's etiological fraction of the cancer risk that F & V prevent. Concluding, chronic health risks investigated are low and health benefits of F & V consumption by far outweigh the PAI-related risk. However, risk estimates are not negligeable and uncertainties remain. Thus, reducing PAI exposure through F & V consumption with a particular focus on priority PAI mentionned above, while maintaining an abundant and varied F & V diet, is desirable.
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