期刊
出版社
WILEY
DOI: 10.1002/trc2.12202
关键词
anti-hypertensives; anti-inflammatories; blood pressure; cholesterol; dementia; diabetes mellitus; homocysteine; hormone therapy; hypertension; inflammation; omega-3 fatty acids
资金
- Australian National Health and Medical Research Centre (NHMRC)
- Dementia Centre for Research Collaboration
- NHMRC
- University of New South Wales
- Canadian Institute for Health Research
- NIH [R01 AG061111, UH3 NS100606, R01AG054130, R01AG061848, R01AG054029, R01AG063689, U19AG010483, R01NS116990, R56AG060608, U24AG057437, R01AG053798, P30AG028383, U19AG068054, R01AG057187, R01NS116058, U19AG024904]
- AbbVie
- Alector
- Biohaven
- Esai
- Lilly
- UK Medical Research Council [MC_UU_12019/1, MC_UU_12019/3]
- UK Alzheimer's Society
- National Institute on Aging [R21AG056518, R01AG055770, R01AG054434, R01AG067063]
- Alzheimer's Society (UK)
- Alzheimer's Drug Discovery Foundation [20140901]
- Sigmund Gestetner Foundation Fellowship
- Alzheimer's Society
- Alzheimer's Research UK
- BRACE
- Bright Focus Foundation
- British Heart Foundation
- UK Medical Research Council
- UK National Institute of Health Research (NIHR-EME)
- Australian Research Council
- Australian Medical Research Futures Fund
- Mindgardens Alliance
- NHMRC Dementia Centre for Research Collaboration
- Australian Government
- The NIH [R01AG051628, R01AG056102, R01AG069782, P30AG066518, R01AG072449, P30AG008017, P30AG024978, U2CAG054397, R01AG056712, R01AG0380651, R21AG062679, P30AG053760, U01NS100611, U2CAG057441, U01NS106670, R01AG054484]
The discrepancies between clinical trial and observational evidence on the impact of health and lifestyle factors on the risk of dementia and Alzheimer's disease have hindered risk reduction. Some interventions, such as non-steroidal anti-inflammatory drugs, have more mature epidemiological evidence, while clinical trial data show promise for anti-hypertensives and B vitamin supplementation to be effective interventions. Further research is needed to improve targeted sample selection, intervention understanding, and data analysis in future clinical trials.
Identifying the leading health and lifestyle factors for the risk of incident dementia and Alzheimer's disease has yet to translate to risk reduction. To understand why, we examined the discrepancies between observational and clinical trial evidence for seven modifiable risk factors: type 2 diabetes, dyslipidemia, hypertension, estrogens, inflammation, omega-3 fatty acids, and hyperhomocysteinemia. Sample heterogeneity and paucity of intervention details (dose, timing, formulation) were common themes. Epidemiological evidence is more mature for some interventions (eg, non-steroidal anti-inflammatory drugs [NSAIDs]) than others. Trial data are promising for anti-hypertensives and B vitamin supplementation. Taken together, these risk factors highlight a future need for more targeted sample selection in clinical trials, a better understanding of interventions, and deeper analysis of existing data.
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