Spatial 3D Mate acute accent rn Priors for Fast Whole-Brain fMRI Analysis

Bayesian whole-brain functional magnetic resonance imaging (fMRI) analysis with three-dimensional spatial smoothing priors has been shown to produce state-of-the-art activity maps without pre-smoothing the data. The proposed inference algorithms are computationally demanding however, and the spatial priors used have several less appealing properties, such as being improper and having infinite spatial range. We propose a statistical inference framework for whole-brain fMRI analysis based on the class of Mate ' rn covariance functions. The framework uses the Gaussian Markov random field (GMRF) representation of possibly anisotropic spatial Mate ' rn fields via the stochastic partial differential equation (SPDE) approach of Lindgren et al. (2011). This allows for more flexible and interpretable spatial priors, while maintaining the sparsity required for fast inference in the high-dimensional whole-brain setting. We develop an accelerated stochastic gradient descent (SGD) optimization algorithm for empirical Bayes (EB) inference of the spatial hyperparameters. Conditionally on the inferred hyperparameters, we make a fully Bayesian treatment of the brain activity. The Mate ' rn prior is applied to both simulated and experimental task-fMRI data and clearly demonstrates that it is a more reasonable choice than the previously used priors, using comparisons of activity maps, prior simulation and cross-validation.

Automated summary

Bayesian whole-brain fMRI analysis based on Mate'rn covariance functions offers a more flexible and interpretable spatial prior, maintaining the sparsity required for fast inference in high-dimensional settings. An accelerated stochastic gradient descent optimization algorithm is used for empirical Bayes inference of spatial hyperparameters, followed by a fully Bayesian treatment of brain activity. The Mate'rn prior is shown to be a more reasonable choice compared to previous priors through comparisons of activity maps, prior simulation, and cross-validation.