期刊
DEVELOPMENT AND PSYCHOPATHOLOGY
卷 33, 期 4, 页码 1229-1247出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954579420000450
关键词
adoption design; differential susceptibility; externalizing; psychopathology factor; social competence
资金
- National Institute of Mental Health [T32 MH014235]
- Yale School of Public Health
- National Institute of Child Health and Human Development [R01 HD042608]
- National Institute on Drug Abuse, NIH, U.S. PHS
- National Institute on Drug Abuse [R01 DA020585]
- National Institute of Mental Health, NIH, U.S. PHS [R01 MH092118]
- Office of the Director, National Institutes of Health [UH3 OD023389]
The Differential Susceptibility Theory suggests that individuals vary in their developmental plasticity, with some being highly responsive to environmental experiences. However, the study found limited evidence supporting this theory and observed that interactions vary depending on the specific environmental factors present. Further investigation is needed before tailoring screening and intervention recommendations based on genetic liability or sensitivity.
Differential susceptibility theory (DST) posits that individuals differ in their developmental plasticity: some children are highly responsive to both environmental adversity and support, while others are less affected. According to this theory, plasticity genes that confer risk for psychopathology in adverse environments may promote superior functioning in supportive environments. We tested DST using a broad measure of child genetic liability (based on birth parent psychopathology), adoptive home environmental variables (e.g., marital warmth, parenting stress, and internalizing symptoms), and measures of child externalizing problems (n = 337) and social competence (n = 330) in 54-month-old adopted children from the Early Growth and Development Study. This adoption design is useful for examining DST because children are placed at birth or shortly thereafter with nongenetically related adoptive parents, naturally disentangling heritable and postnatal environmental effects. We conducted a series of multivariable regression analyses that included Gene x Environment interaction terms and found little evidence of DST; rather, interactions varied depending on the environmental factor of interest, in both significance and shape. Our mixed finYdings suggest further investigation of DST is warranted before tailoring screening and intervention recommendations to children based on their genetic liability or sensitivity.
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