期刊
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
卷 14, 期 -, 页码 -出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/17562848211016959
关键词
combination treatment; hepatocellular carcinoma (HCC); regorafenib; systemic treatment; tyrosine kinase inhibitor (TKI)
Regorafenib, structurally similar to sorafenib, shows significant survival advantage in unresectable hepatocellular carcinoma (HCC) patients who failed first-line treatment, by targeting angiogenic and tumor growth-promoting pathways, inhibiting tumor neo-angiogenesis and proliferation, and modulating the tumor microenvironment. It is being explored for use in combination therapy with immune checkpoint blockade and for extended use in patient categories beyond registrative studies.
Regorafenib is a diphenylurea oral multikinase inhibitor, structurally comparable to sorafenib, which targets a variety of kinases implicated in angiogenic and tumor growth-promoting pathways. Regorafenib was the first agent to positively show significant survival advantage as a second-line therapy in patients with unresectable hepatocellular carcinoma (HCC) who had previously failed first-line treatment with sorafenib. Recent evidence has shown that its antitumor efficacy is due to a comprehensive spectrum of tumor neo-angiogenesis and proliferation inhibition and immunomodulatory effects on the tumor microenvironment, which plays a crucial role in tumor development. This review addresses the rationale and supporting evidence for regorafenib's efficacy in HCC that led to regorafenib's approval as a second-line therapy. In addition, we review proof from clinical practice studies that validate the RESORCE trial results. We discuss regorafenib's potential role in the newly emerging therapeutic strategy based on combination with immune checkpoint blockade and its possible extensibility to patient categories not enrolled in the registrative study.
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