Exploration of Antioxidant, Antibacterial Activities of Green Synthesized Hesperidin Loaded PLGA Nanoparticles

To elaborate on the potential benefits of hesperidin loaded PLGA nanoparticles (HES-PLGA NPs), present investigation reports about the antioxidant, antimicrobial, and cytotoxic potential of hesperidin loaded PLGA nanoparticles (HES-PLGA-NPs). The antioxidant potential of Hesperidin and HES-PLGA-NPs was demonstrated by ATBS, DPPH, Hydroxy, Hydrogen peroxide, and superoxide radical showing the dose-dependent antioxidants activity. Both the test gained better potential with HES loaded PLGA nanoparticles than free HES. HES-PLGA-NPs also proved its antibacterial activity against tested bacterial strains, including Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, and Pseudomonas aeruginosa. HES-PLGA-NPs had a good ability to minimize biofilms' formation and a good to weak ability to degrade pre-formed biofilms. Thus, the bionanotherapy, which has been attempted using HES-PLGA-NPs would provide a promising scope as a potent bio compound that can be replaced for medical ailments in a cost-effective, greener synthesis.

Automated summary

This study demonstrates the antioxidant and antimicrobial potential of hesperidin loaded PLGA nanoparticles, showing better activity compared to free hesperidin. The nanoparticles also exhibited the ability to inhibit biofilm formation, suggesting their promising application as a bio compound for medical treatments.