4.7 Article

Heterogeneity of Response to Iron-Based Metallodrugs in Glioblastoma Is Associated with Differences in Chemical Structures and Driven by FAS Expression Dynamics and Transcriptomic Subtypes

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Inorganic & Nuclear

Multifaceted chemical behaviour of metallocene (M = Fe, Os) quinone methides. Their contribution to biology

Anne Vessieres et al.

Summary: Organometallic quinone methides (OM-QMs) exhibit unique chemical and biological properties when incorporated into specific substrates like ferrocifens, leading to disruption of cancer cell metabolism and cytotoxicity. Among these, ferrocifens show the highest toxicity within the iron, ruthenium, osmium triad, and the complexes can be utilized as imaging probes.

COORDINATION CHEMISTRY REVIEWS (2021)

Article Biochemistry & Molecular Biology

A Drug Screening Pipeline Using 2D and 3D Patient-Derived In Vitro Models for Pre-Clinical Analysis of Therapy Response in Glioblastoma

Sakthi Lenin et al.

Summary: This study conducted a systematic review on the molecular mechanisms driving glioblastoma progression, identifying 65 drugs/inhibitors for screening their efficacy on patient-derived glioma stem cells. Costunolide, a TERT inhibitor, was found effective in reducing cell viability in both primary and pre-treated tumor models. This novel workflow could lead to personalized and effective treatment for recurrent glioblastoma.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

ROS in cancer therapy: the bright side of the moon

Bruno Perillo et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2020)

Review Oncology

Characterization of molecular pathways for targeting therapy in glioblastoma

Naveed Wagle et al.

CHINESE CLINICAL ONCOLOGY (2020)

Article Chemistry, Multidisciplinary

Atypical Lone Pair-π Interaction with Quinone Methides in a Series of Imido-Ferrociphenol Anticancer Drug Candidates

Yong Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)

Review Biochemistry & Molecular Biology

Glioblastoma heterogeneity and the tumour microenvironment: implications for preclinical research and development of new treatments

Sally L. Perrin et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Biochemistry & Molecular Biology

Pharmaco-genomic investigations of organo-iridium anticancer complexes reveal novel mechanism of action

Jessica M. Hearn et al.

METALLOMICS (2018)

Review Oncology

Oxaliplatin in the era of personalized medicine: from mechanistic studies to clinical efficacy

Paola Perego et al.

CANCER CHEMOTHERAPY AND PHARMACOLOGY (2016)

Article Multidisciplinary Sciences

Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State

Alessandra Folda et al.

SCIENTIFIC REPORTS (2016)

Article Chemistry, Multidisciplinary

Organometallic Antitumor Compounds: Ferrocifens as Precursors to Quinone Methides

Yong Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Chemistry, Multidisciplinary

Ferrocifen type anti cancer drugs

Gerard Jaouen et al.

CHEMICAL SOCIETY REVIEWS (2015)

Article Multidisciplinary Sciences

Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells

Jessica M. Hearn et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Biochemistry & Molecular Biology

The Molecular Signatures Database Hallmark Gene Set Collection

Arthur Liberzon et al.

CELL SYSTEMS (2015)

Article Biochemistry & Molecular Biology

The Somatic Genomic Landscape of Glioblastoma

Cameron W. Brennan et al.

Review Oncology

Individualized Targeted Therapy for Glioblastoma Fact or Fiction?

Michael Weller et al.

CANCER JOURNAL (2012)

Article Chemistry, Multidisciplinary

Deciphering the Activation Sequence of Ferrociphenol Anticancer Drug Candidates

Pierluca Messina et al.

CHEMISTRY-A EUROPEAN JOURNAL (2012)

Article Biochemistry & Molecular Biology

A ferrocenyl derivative of hydroxytamoxifen elicits an estrogen receptor-independent mechanism of action in breast cancer cell lines

Anne Vessieres et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2010)

Article Chemistry, Multidisciplinary

Ferrocenyl Quinone Methides as Strong Antiproliferative Agents: Formation by Metabolic and Chemical Oxidation of Ferrocenyl Phenols

Didier Hamels et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2009)

Article Public, Environmental & Occupational Health

Promoter Methylation and Polymorphisms of the MGMT Gene in Glioblastomas: A Population-Based Study

Izabela Zawlik et al.

NEUROEPIDEMIOLOGY (2009)

Article Biochemistry & Molecular Biology

Evaluation of cytotoxic properties of organometallic ferrocifens on melanocytes, primary and metastatic melanoma cell lines

Qq Michard et al.

JOURNAL OF INORGANIC BIOCHEMISTRY (2008)

Review Clinical Neurology

The 2007 WHO classification of tumours of the central nervous system

David N. Louis et al.

ACTA NEUROPATHOLOGICA (2007)

Article Medicine, General & Internal

Radiotherapy for glioblastoma in the elderly

Florence Keime-Guibert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Article Oncology

French brain tumor data bank: Methodology and first results on 10,000 cases

Luc Bauchet et al.

JOURNAL OF NEURO-ONCOLOGY (2007)

Review Biochemistry & Molecular Biology

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

S. Fulda et al.

ONCOGENE (2006)

Article Chemistry, Multidisciplinary

Ferrocene-mediated proton-coupled electron transfer in a series of ferrocifen-type breast-cancer drug candidates

E Hillard et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)

Article Medicine, General & Internal

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma

R Stupp et al.

NEW ENGLAND JOURNAL OF MEDICINE (2005)

Article Chemistry, Inorganic & Nuclear

Studies on organometallic selective estrogen receptor modulators.: (SERMs) Dual activity in the hydroxy-ferrocifen series

S Top et al.

JOURNAL OF ORGANOMETALLIC CHEMISTRY (2001)

Article Chemistry, Inorganic & Nuclear

On the mechanism of the antitumor activity of ferrocenium derivatives

D Osella et al.

INORGANICA CHIMICA ACTA (2000)