期刊
ADVANCED NANOBIOMED RESEARCH
卷 1, 期 8, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anbr.202100016
关键词
antioxidants; biomaterials; cerium; coatings; diabetes
资金
- NIH [DK100654, DK126413]
- T32 Interdisciplinary Graduate Program in Type 1 Diabetes and Biomedical Engineering Predoctoral Training Grant [DK108736]
Imbalance of oxidants leads to failure of implanted devices and tissues. Antioxidant materials, such as cerium oxide nanoparticles, can inhibit this cycle and enhance implant efficacy. The deposition of CONP coatings, based on certain parameters, can customize antioxidant properties and provide protection to encapsulated cells.
Imbalance of oxidants is a universal contributor to the failure of implanted devices and tissues. A sustained oxidative environment leads to cytotoxicity, prolonged inflammation, and ultimately host rejection of implanted devices/grafts. The incorporation of antioxidant materials can inhibit this redox/inflammatory cycle and enhance implant efficacy. Cerium oxide nanoparticle (CONP) is a highly promising agent that exhibits potent, ubiquitous, and self-renewable antioxidant properties. Integrating CONP as surface coatings provides ease in translating antioxidant properties to various implants/grafts. Herein, the formation of CONP coatings, generated via the sequential deposition of CONP and alginate, and the impact of coating properties, pH, and polymer molecular weight, on their resulting redox profile are described. Investigation of CONP deposition, layer formation, and coating uniformity/thickness on their resulting oxidant scavenging activity identify key parameters for customizing global antioxidant properties. Results found lower molecular weight alginates and physiological pH shift CONP activity to a higher H2O2 to O-2(-)-scavenging capability. The antioxidant properties measured for these various coatings translate to distinct antioxidant protection to the underlying encapsulated cells. Information gained from this work can be leveraged to tailor coatings toward specific oxidant-scavenging applications and prolong the function of medical devices and cellular implants.
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