Cell-Based Bio-Hybrid Delivery System for Disease Treatments

Live cells are implicated in diverse biological processes, including nutrient transport and removal of foreign substances. Their intelligent biofunctions with complex mechanisms cannot be replicated at all in man-made materials despite the significant advance in material design. Taking advantages of their biocompatibility and biotropic capability, various live cells have been developed as a kind of special carriers for the on-demand delivery of therapeutic and diagnostic agents in recent years. Furthermore, synthetic materials can be integrated with live cells to provide bio-hybrid systems that inherit advantages from both the synthetic particles and the natural cells. Herein, recent strategies and advances in cell-based bio-hybrid delivery systems for disease treatment are summarized. Challenges and opportunities in this field are also discussed.

Automated summary

Live cells have been developed as special carriers for on-demand delivery of therapeutic and diagnostic agents, utilizing their biocompatibility and biotropic capability. Bio-hybrid systems combining synthetic materials with live cells inherit advantages from both components. This article summarizes recent strategies and advances in cell-based bio-hybrid delivery systems for disease treatment, while also discussing challenges and opportunities in the field.