期刊
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA
卷 46, 期 4, 页码 1009-1038出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ecl.2017.07.007
关键词
Vitamin D; Chemoprevention; Chemotherapy; TCGA; Genomics
资金
- Prostate program of the Department of Defense Congressionally Directed Medical Research Programs [W81XWH-14-1-0608, W81XWH-11-2-0033]
- Inova Schar Cancer Institute
- generosity of the Schar Family
The vitamin D receptor (VDR) binds the secosteroid hormone 1,25(OH)(2)D-3 with high affinity and regulates gene programs that control serum calcium levels, as well as cell proliferation and differentiation. A significant focus has been to exploit the VDR in cancer settings. Although preclinical studies have been strongly encouraging, to date clinical trials have delivered equivocal findings that have paused the clinical translation of these compounds. However, it is entirely possible that mining of genomic data will help define precisely what the key anticancer actions of vitamin D compounds are and where these can be used most effectively.
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