期刊
出版社
IEEE
DOI: 10.1109/BIOCAS49922.2021.9644991
关键词
implant drug delivery system; ultrasound wireless power and data; potentiostat; bidirectional communication
类别
资金
- NIH NIBIB [R01EB025867]
- NSF CAREER Award [ECCS1454107]
- Dr. Robert Noyce Stanford Graduate Fellowship
This study presents an ultrasonically powered implantable potentiostat for programmable drug delivery control. The system is complex, consisting of multiple functional modules for bidirectional communication and drug release. The wireless powered and controlled fluorescein release successfully demonstrates the system's effectiveness.
Implantable drug delivery systems can enable targeted, personalized, and on-demand treatments while minimizing the risk of side effects. In this work, we present an ultrasonically powered implantable potentiostat with bidirectional communication for programmable electrochemically controlled drug delivery. The system consists of piezoelectric transducers for wireless power and data, a 180 nm CMOS integrated circuit, and a custom drug delivery module containing drug-loaded electroresponsive nanoparticles. The chip includes power and downlink data recovery circuits for simultaneous power and data transfer up to 50 kbps, a programmable wide-range potentiostat capable of providing potentials up to +/- 1.5 V and sensing current up to +/- 100 mu A, and a 125 kbps data transmitter. Wirelessly powered and controlled fluorescein release is used to demonstrate the drug delivery system.
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