Natural surfactants assisted an efficient synthesis of tetrahydro-β-carbolines

An expeditious protocol for the synthesis of structurally diversified beta-carboline derivatives has been reported using a readily available natural surfactant medium. The synthesis of beta-carboline derivatives in good yields under optimized conditions was carried out by the reaction of tryptamine with aldehydes in an aqueous extract of Acacia Concinna pods. The use of an aqueous medium, ease of purification, good yield and cost-effective reaction suggest for bulk scale production beta-carboline derivatives.

Automated summary

The synthesis of structurally diversified beta-carboline derivatives using a readily available natural surfactant medium has been reported. The reaction of tryptamine with aldehydes in an aqueous extract of Acacia Concinna pods yielded good results, suggesting potential for cost-effective large-scale production of beta-carboline derivatives.