期刊
JORNAL BRASILEIRO DE NEFROLOGIA
卷 43, 期 2, 页码 173-181出版社
SOC BRASILEIRA NEFROLOGIA
DOI: 10.1590/2175-8239-JBN-2020-0147
关键词
Phosphorus; Calcium; Renal Insufficiency; Chronic
The study aimed to describe the prevalence of CKDMBD biomarkers in a large cohort of PD patients in Brazil. The findings showed a significant presence of biochemical disorders related to CKD-MBD in this dialysis population.
Introduction: Chronic kidney disease - mineral and bone disorders (CKD-MBD) are common in dialysis patients. Definition of targets for calcium (Ca), phosphorus (P), parathormone (iPTH), and alkaline phosphatase (ALP) and their treatment recommendations, are provided by international guidelines. There are few studies analyzing CKD-MBD in peritoneal dialysis (PD) patients and the impact of guidelines on mineral metabolism control. The aim of our study was to describe the prevalence of biomarkers for CKDMBD in a large cohort of PD patients in Brazil. Methods: Data from the nationwide prospective observational cohort BRAZPD II was used. Incident patients were followed between December 2004 and January 2011. According to KDOQI recommendations, reference ranges for total Ca were 8.4 to 9.5 mg/dL, for P, 3.5 to 5.5 mg/dL, for iPTH, 150-300 pg/mL, and for ALP, 120 U/L. Results: Mean age was 59.8 +/- 16 years, 48% were male, and 43% had diabetes. In the beginning, Ca was 8.9 +/- 0.9 mg/dL, and 48.3% were on the KODQI target. After 1 year, Ca increased to 9.1 +/- 0.9 mg/dL and 50.4% were in the KDOQI preferred range. P at baseline was 5.2 +/- 1.6 mg/dL, with 52.8% on target, declining to 4.9 +/- 1.5 mg/dL after one year, when 54.7% were on target. Median iPTH at baseline was 238 (P25% 110 - P75% 426 pg/mL) and it remained stable throughout the first year; patients within target ranged from 26 to 28.5%. At the end of the study, 80% was in 3.5 meq/L Ca dialysate concentration, 66.9% of patients was taking any phosphate binder, and 25% was taking activated vitamin D. Conclusions: We observed a significant prevalence of biochemical disorders related to CKD-MBD in this dialysis population.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据