期刊
BIOMEDICAL JOURNAL
卷 39, 期 1, 页码 5-13出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bj.2015.08.003
关键词
Arsenic As(III) S-adenosylmethionine methyltransferase; C-As lyase; Methylarsenite oxidase; Organoarsenical
资金
- Bankhead-Coley Program from State of Florida, Department of Health [4BF01]
- National Institutes of Health [R37 GM55425, R01 ES023779]
Arsenic is the most pervasive environmental substance and is classified by the International Agency for Research on Cancer as a Group 1 human carcinogen. Nearly every organism has resistance pathways for inorganic arsenic, and in bacteria, their genes are found in arsenic resistance (ars) operons. Recently, a parallel pathway for organic arsenicals has been identified. The ars genes responsible for the organoarsenical detoxification includes arsM, which encodes an As(III) S-adenosylmethionine methyltransferase, arsI, which encodes a C-As bond lyase, and arsH, which encodes a methylarsenite oxidase. The identification and properties of arsM, arsI and arsH are described in this review.
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