期刊
CELL ADHESION & MIGRATION
卷 15, 期 1, 页码 180-201出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19336918.2021.1935407
关键词
Exosomes; miRNAs; tumor invasion; breast cancer; glioblastoma; prostate cancer
类别
MiRNAs and exosomes play crucial roles in cellular invasion process by regulating gene expression and cell processes. The study found significant differential abundance of certain miRNAs during cell invasion, providing insight into the language codes among cells and potential for developing therapies to inhibit cellular communication.
MiRNAs represent a mechanism that regulates gene expression in many pathological conditions. Exosomes are known to be secreted from all types of cells, and the exosomes-released molecules are crucial messengers that can regulate cellular processes. We investigated the miRNAs content of exosomes released by cancer cells during the invasion . An invasion stimulus has been generated through scratches created on the confluent cells of cancer cell lines: glioblastoma, breast and prostate cancers. Several miRNAs were found to be significantly differentially abundant during the cell invasion , both in common among different cell lines and exclusive. Understanding the language codes among cells involved in invasion can lead to the development of therapies that can inhibit cellular communication, slowing or eventually stopping their activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据