期刊
VIROLOGICA SINICA
卷 31, 期 5, 页码 363-379出版社
SPRINGER
DOI: 10.1007/s12250-016-3889-z
关键词
three-dimensional (3D) cell culture models; scaffolds; human viruses
类别
资金
- National Mega-projects for Infectious Diseases [2014ZX10004002-004-001]
Three-dimensional (3D) culture models are physiologically relevant, as they provide reproducible results, experimental flexibility and can be adapted for high-throughput experiments. Moreover, these models bridge the gap between traditional two-dimensional (2D) monolayer cultures and animal models. 3D culture systems have significantly advanced basic cell science and tissue engineering, especially in the fields of cell biology and physiology, stem cell research, regenerative medicine, cancer research, drug discovery, and gene and protein expression studies. In addition, 3D models can provide unique insight into bacteriology, virology, parasitology and host-pathogen interactions. This review summarizes and analyzes recent progress in human virological research with 3D cell culture models. We discuss viral growth, replication, proliferation, infection, virus-host interactions and antiviral drugs in 3D culture models.
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