期刊
IMMUNE NETWORK
卷 16, 期 5, 页码 271-280出版社
KOREA ASSOC IMMUNOLOGISTS
DOI: 10.4110/in.2016.16.5.271
关键词
Tertiary lymphoid structures; Autoimmunity; Inflammation
类别
资金
- National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology of Korea [2011-0014447]
- National Research Foundation of Korea [2011-0014447] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Tertiary lymphoid structures (TLS) are ectopic lymphoid tissues involved in chronic inflammation, autoimmune diseases, transplant rejection and cancer. They exhibit almost all the characteristics of secondary lymphoid organs (SLO), which are associated with adaptive immune responses; as such, they contain organized B-cell follicles with germinal centers, distinct areas containing T cells and dendritic cells, high endothelial venules, and lymphatics. In this review, we briefly describe the formation of SLO, and describe the cellular subsets and molecular cues involved in the formation and maintenance of TLS. Finally, we discuss the associations of TLS with human diseases, especially autoimmune diseases, and the potential for therapeutic targeting.
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