期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 1, 页码 390-395出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1762190
关键词
H-1 NMR spectroscopy; metabolite fingerprinting; Momordica charantia; phytomedicinal compounds; antioxidant activity
The study identified that Momordica charantia fruit's pericarp and seeds are rich in phenolic compounds and flavonoids, making them good sources of antioxidants. On the other hand, the skin contains a significant amount of phytosterols such as Charantin and momordicine, which are associated with anti-diabetic activity.
Momordica charantia is a medicinal plant which is widely used in different traditional medicinal systems to treat several diseases. We have identified the differential distribution of phytomedicinally important metabolites in the pericarp, skin and seeds of M. charantia fruit via NMR spectroscopy. Multivariate statistical analysis showed a clustering of the metabolic profiles of seeds and pericarp, and their clear separation from the metabolic profile of the skin. The total phenolic and flavonoid content of the fruit extracts were estimated via bioassays, the radical scavenging activity was estimated via in vitro DPPH and ABTS assays and an inhibitory activity test of alpha-glucosidase was also performed. The pericarp and seeds contained significant amounts of phenolic compounds and flavonoids, indicating that they are a good source for antioxidants. The skin contained a significantly higher amount of phytosterols such as Charantin and momordicine, which are known to correlate with antidiabetic activity.
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