期刊
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
卷 52, 期 5, 页码 933-948出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10408347.2020.1843131
关键词
Biological samples; disease biomarkers; molecularly imprinted polymers; sample preparation; solid phase extraction
资金
- Fundacaoa Pesquisa do Estado de Minas Gerais (FAPEMIG, Belo Horizonte, Brazil) [88881.133746/2016-01]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq, Brasilia, Brazil) [88881.133746/2016-01]
- Coordination for the Improvement of Higher Education Personnel (CAPES, Brasilia, Brazil) [88881.133746/2016-01]
This review discusses the rational design and applications of molecularly imprinted polymers (MIPs) in solid phase extraction of disease biomarkers from biological samples, as well as the remaining challenges and future trends in the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.
Low concentrations of biomarkers as well as the complexity of biological samples make the clinical diagnoses of several diseases a challenging task. Sample preparation protocols remain a fundamental piece in the puzzle of analytical processes, and smart sorbents including molecularly imprinted polymers (MIPs) have been successfully used in this case. In this review, we depict the state of art for the rational design of MIPs to be used in solid phase extraction of disease biomarkers from biological samples. The topics are divided into (1) strategies for MIP syntheses, (2) setups for sample preparation protocols with MIPs, (3) the applications of these combined principles in the analyses of different classes of disease biomarkers, and (4) remaining challenges and future trends for the application of Molecular Imprinting Technology in sample preparation for clinical diagnosis.
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