期刊
NATURAL PRODUCT RESEARCH
卷 36, 期 8, 页码 2171-2176出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2020.1845672
关键词
Triclisia gilletii; gas chromatography-mass spectrometry; liquid chromatography-mass spectrometry; phytochemicals; nephroprotection
资金
- centre for international cooperation and development (CICOPS) university of Pavia, Italy
The phytochemical constituents in the aqueous methanolic leaf extract of Triclisia gilletii responsible for its nephroprotective potentials against ethane-1,2-diol induced nephrolithiasis were elucidated. Phenols, fatty acids, vitamins, and steroids were detected using both gas chromatography and liquid chromatography. Kaempferol and dihydrovomifoliol-O-glucoside were also identified. These constituents contribute to the pharmacological potential of Triclisia gilletii against ethane-1,2-diol induced nephrolithiasis.
The phytochemical constituents in the aqueous methanolic leaf extract of Triclisia gilletii responsible for its nephroprotective potentials against ethane-1,2-diol induced nephrolithiasis as previously investigated in our laboratory were elucidated. The extract was prepared using 80% aqueous methanol in 72 h, Phytochemical contents of aqueous methanolic extract of Triclisia gilletii (TGME) was identified using both a Thermo Scientific DSQII single quadrupole gas chromatography (GC) and a Thermo Scientific liquid chromatography (LCQ Fleet system) tandem mass spectroscopy. The chromatogram acquisition, detection of mass spectral peaks and their waveform processing were performed using Xcalibur MS Software (Thermo Scientific Inc.). GC-MS analysis revealed the presence of phenols, fatty acids, vitamins and steroids. Likewise, for LC-MS analysis kaempferol and dihydrovomifoliol-O-glucoside were detected. The identified constituents have possible contributively effect on the acclaimed pharmacological potential of Triclisia gilletii against ethane-1,2-diol induced nephrolithiasis.
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