Synthetic MRI: Technologies and Applications in Neuroradiology

Synthetic MRI is a technique that synthesizes contrast-weighted images from multicontrast MRI data. There have been advances in synthetic MRI since the technique was introduced. Although a number of synthetic MRI methods have been developed for quantifying one or more relaxometric parameters and for generating multiple contrast-weighted images, this review focuses on several methods that quantify all three relaxometric parameters (T-1, T-2, and proton density) and produce multiple contrast-weighted images. Acquisition, quantification, and image synthesis techniques are discussed for each method. We discuss the image quality and diagnostic accuracy of synthetic MRI methods and their clinical applications in neuroradiology. Based on this analysis, we highlight areas that need to be addressed for synthetic MRI to be widely implemented in the clinic. Level of Evidence 5 Technical Efficacy Stage 1

Automated summary

This review discusses the advances and applications of synthetic MRI, focusing on methods that quantify all relaxometric parameters and generate multiple contrast-weighted images. The acquisition, quantification, and image synthesis techniques of each method are discussed, as well as the image quality, diagnostic accuracy, and clinical applications in neuroradiology.