期刊
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS
卷 52, 期 2, 页码 483-489出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10803-021-04941-w
关键词
Autism spectrum disorder; Neonatal jaundice; Polymorphism; Dried umbilical cord
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [17K16299, 170002]
- Grants-in-Aid for Scientific Research [17K16299] Funding Source: KAKEN
The study found no significant association between neonatal jaundice and ASD when examining UGT1A1 polymorphisms. There was no UGT1A1*27 allele detected in the subjects, and ASD symptom assessment scores were not associated with genotypes or diplotypes.
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.
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