期刊
NATURE REVIEWS IMMUNOLOGY
卷 22, 期 2, 页码 97-111出版社
NATURE PORTFOLIO
DOI: 10.1038/s41577-021-00557-4
关键词
-
类别
资金
- Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III [PI19/855]
- European Regional Development Fund (ERDF)
- European Commission through H2020-EU.1.1, European Research Council grant [ERC-2016-StG 715322-EndoMitTalk]
- Madrid Government (Comunidad de Madrid-Spain)
- Universidad Autonoma de Madrid [SI1/PJI/2019-00073]
- Miguel Servet Program (Fundacion de Investigacion del Hospital 12 de Octubre) [CP 19/014]
- FPU grant from Ministerio de Ciencia, Innovacion y Universidades (Spain) [FPU19/02576]
- Juan de la Cierva grant from Ministerio de Ciencia, Innovacion y Universidades (Spain) [IJC2018-036850-I]
T cells play a crucial role in age-related diseases, potentially leading to the failure of immune tolerance mechanisms and tissue damage. Targeting T cells could offer new therapeutic opportunities to enhance resilience to age-related diseases.
In this Review, Maria Mittelbrunn and colleagues highlight the involvement of T cells in diseases associated with ageing. In particular, the authors discuss how T cells contribute to inflammageing and the potential of targeting these populations for therapy of age-related diseases. Age-related T cell dysfunction can lead to failure of immune tolerance mechanisms, resulting in aberrant T cell-driven cytokine and cytotoxic responses that ultimately cause tissue damage. In this Review, we discuss the role of T cells in the onset and progression of age-associated conditions, focusing on cardiovascular disorders, metabolic dysfunction, neuroinflammation and defective tissue repair and regeneration. We present different mechanisms by which T cells contribute to inflammageing and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota. Finally, we propose that 'resetting' immune system tolerance or targeting pathogenic T cells could open up new therapeutic opportunities to boost resilience to age-related diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据