Association between FTO (rs17817449) genetic variant, gamma-glutamyl transferase, and hypertension in Slovak midlife women

Objectives This cross-sectional study investigates associations between the FTO rs 17817449 genetic variant, liver enzymes, and hypertension in Slovak midlife women. Methods We assessed 576 Slovak women aged 39 to 65 years. The women were interviewed and examined during their medical examination at local Health Centers and then divided into subgroups according to their blood pressure status; 255 women with hypertension and 321 normotensive. The FTO genetic variant was detected by polymerase chain reaction-restriction fragment length polymorphism. Resultant data was analyzed by linear regression analysis and general linear models to adjust for risk factors associated with gamma-glutamyl transferase levels (GGT), including waist to hip ratio (WHR) and uric acid (UA). Results A significant association between the FTO variant and GGT levels was observed in the hypertensive group after control for confounding covariates, including WHR and UA (p = .004). The predicted GGT level for GT/TT hypertensive carriers is 0.158 mu kat/L higher than for GG carriers. Moreover, the two-way analysis of covariance revealed significant interaction between FTO effects and hypertension on logGGT levels (p = .042). Finally, hypertensive women with the T-allele had the highest estimated marginal mean value of logGGT at -0.39 mu kat/L while the GG-genotype in both hypertensive and normotensive women had the lowest value at -0.54 mu kat/L. Conclusions This study suggests that the FTO (rs17817449) variant is associated with higher serum GGT levels in hypertensive midlife women.

Automated summary

This cross-sectional study found that the FTO rs17817449 genetic variant is associated with higher serum GGT levels in hypertensive midlife women. The predicted GGT levels were higher in GT/TT hypertensive carriers compared to GG carriers. Additionally, there was a significant interaction between FTO effects and hypertension on GGT levels.