期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 606, 期 -, 页码 1779-1791出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2021.08.155
关键词
Halloysite nanotubes; Site-specific functionalization; Polydopamine; Secondary modification; Biotin-avidin interaction; Delivery system; Hyperthermia effects
资金
- University of Palermo
- PON AIM: Attrazione e Mobilita Internazionale project [1808223-1]
- Italian Ministry of Education and Research (MIUR) [a3_00363]
- European Union [823717]
This study achieved the site-selective functionalization of HNTs with polydopamine by exploiting the basicity of ZnO nanoparticles anchored on the HNTs external surface. The introduction of PDA coating affected the aqueous stability of the nanotubes and induced a local thermal rise under near-infrared irradiation.
Halloysite nanotubes (HNTs) represent a versatile core structure for the design of functional nanosystems of biomedical interest. However, the development of selective methodologies for the site-controlled functionalization of the nanotubes at specific sites is not an easy task. This study aims to accomplish a procedure for the site-selective/specific, pin-point, functionalization of HNTs with polydopamine (HNTs@PDA). This goal was achieved, at pH 6.5, by exploiting the basicity of ZnO nanoparticles anchored on the HNTs external surface (HNTs@ZnO) to induce a punctual polydopamine polymerization and coating. The morphology and the chemical composition of the nanomaterial was demonstrated by several techniques. Turbidimetric analysis showed that PDA coating affected the aqueous stability of HNTs@PDA compared to both HNTs@ZnO and HNTs. Notably, hyperthermia studies revealed that the nanomaterial induced a local thermic rise, up to 50 degrees C, under near-infrared (NIR) irradiation. Furthermore, secondary functionalization of HNTs@PDA by selective grafting of biotin onto the PDA coating followed by avidin binding was also accomplished. (c) 2021 Elsevier Inc. All rights reserved.
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