4.2 Article

Mildly Increased Mechanical Nociceptive Sensitivity in REV-ERBa Knock-out Mice

期刊

EXPERIMENTAL NEUROBIOLOGY
卷 25, 期 6, 页码 342-346

出版社

KOREAN SOC BRAIN & NEURAL SCIENCE, KOREAN SOC NEURODEGENERATIVE DISEASE
DOI: 10.5607/en.2016.25.6.342

关键词

Circadian rhythm; REV-ERBa; Nociception; Inflammatory pain

资金

  1. National Research Foundation (NRF) of Korea-Korean government (MSIP) [NRF-2012R1A3A1050385]
  2. National Research Foundation (NRF) of Korea- Korean government (MSIP) [35B-2011-1-C00034]
  3. National Research Foundation of Korea [35B-2011-1-C00034] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Nociception is one of the most complex senses that is affected not only by external stimulation but also internal conditions. Previous studies have suggested that circadian rhythm is important in modulating nociception. REV-ERBa knock-out (KO) mice have disrupted circadian rhythm and altered mood-related phenotypes. In this study, we examined the role of REV-ERBa in inflammatory nociception. We found that the nociceptive sensitivity of KO mice was partially enhanced in mechanical nociception. However, this partial alteration was independent of the circadian rhythm. Taken together, deletion of REV-ERBa induced a mild change in mechanical nociceptive sensitivity but this alteration was not dependent on the circadian rhythm.

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