期刊
MICROBIAL BIOTECHNOLOGY
卷 9, 期 4, 页码 452-465出版社
WILEY
DOI: 10.1111/1751-7915.12368
关键词
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资金
- Winclove Probiotics BV
- European Research Council (ERC) [250172 - Microbes Inside]
- Academy of Finland [141130]
- Gravity grant of the Netherlands Organization for Scientific Research (NWO) [SIAM 024.002.002]
- Spinoza grant of the Netherlands Organization for Scientific Research (NWO)
Lactobacillus plantarum WCFS1 is one of the best studied Lactobacilli, notably as its genome was unravelled over 12years ago. L.plantarum WCFS1 can be grown to high densities, is amenable to genetic transformation and highly robust with a relatively high survival rate during the gastrointestinal passage. In this review, we present and discuss the main insights provided by the functional genomics research on L.plantarum WCFS1 with specific attention for the molecular mechanisms related to its interaction with the human host and its potential to modify the immune system, and induce other health-related benefits. Whereas most insight has been gained in mouse and other model studies, onlyfive human studies have been reported with L.plantarum WCFS1. Hence NCIMB 8826 (the parental strain of L.plantarum WCFS1) in human trials as to capitalize on the wealth of knowledge that is summarized here.
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