期刊
MICROBIAL BIOTECHNOLOGY
卷 10, 期 2, 页码 250-263出版社
WILEY
DOI: 10.1111/1751-7915.12363
关键词
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资金
- Fundacao para a Ciencia e a Tecnologia, I.P. (FCT), Portugal [IF/01203/2013/CP1163/CT0002]
- European Union [634486]
- Fundação para a Ciência e a Tecnologia [IF/01203/2013/CP1163/CT0002] Funding Source: FCT
Microorganisms have been exposed to a myriad of substrates and environmental conditions throughout evolution resulting in countless metabolites and enzymatic activities. Although mankind have been using these properties for centuries, we have only recently learned to control their production, to develop new biocatalysts with high stability and productivity and to improve their yields under new operational conditions. However, microbial cells still provide the best known environment for enzymes, preventing conformational changes in the protein structure in non-conventional medium and under harsh reaction conditions, while being able to efficiently regenerate necessary cofactors and to carry out cascades of reactions. Besides, a still unknown microbe is probably already producing a compound that will cure cancer, Alzeihmer's disease or kill the most resistant pathogen. In this review, the latest developments in screening desirable activities and improving production yields are discussed.
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