期刊
HEPATOLOGY COMMUNICATIONS
卷 6, 期 5, 页码 1227-1235出版社
JOHN WILEY & SONS LTD
DOI: 10.1002/hep4.1865
关键词
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资金
- National Institute on Aging [R01AG059183]
- National Institute of Diabetes and Digestive and Kidney Diseases [5T32DK060414-18]
- American Association for the Study of Liver Diseases (Advanced/Transplant Hepatology Award)
- University of California, San Francisco (MATCH Research Center, Team Science Grant [Resource Allocation Program])
- Liver Center, University of California, San Francisco [P30DK026743]
Racial/ethnic minorities experience higher rates of wait-list mortality and longer waiting times on the liver transplant wait list. Hispanics and multiracial/other ethnicity patients are more likely to decline organ offers due to logistical reasons, with logistical patients having higher allocation scores and longer waiting times.
Racial/ethnic minorities experience higher rates of wait-list mortality and longer waiting times on the liver transplant wait list. We hypothesized that racial/ethnic minorities may encounter greater logistical barriers to maintaining readiness on the wait list, as reflected in offer nonacceptance. We identified all candidates who received an organ offer between 2009 and 2018 and investigated candidates who did not accept an organ offer using a free-text refusal reason associated with refusal code 801. We isolated patients who did not accept an organ offer due to candidate-related logistical reasons and evaluated their characteristics. We isolated 94,006 no 801 patients and 677 with 801 logistical patients. Common reasons for offer decline among the 677 were 60% unable to travel/distance, 22% cannot be contacted, 13% not ready/unspecified, and 5% financial/insurance. Compared to no 801, with 801 logistical patients were more likely to be Hispanic (19% vs. 15%, P < 0.01). Multivariate logistic modeling showed Hispanic (odds ratio [OR] 1.44, 95% confidence interval [CI] 1.17-1.76, P < 0.01) and multiracial/other ethnicity (OR 1.82, 95% CI 1.08-3.05, P = 0.02) were associated with with 801 logistical status. The with 801 logistical patients were listed with higher allocation (inclusive of exception points) Model for End-Stage Liver Disease scores (16 vs. 15, P < 0.01) and remained longer on the wait list (median 428 days vs. 187 days, P < 0.01). Conclusion: In this analysis of wait-list candidates, we isolated 677 patients who declined an organ offer with a free-text reason consistent with a candidate-related logistical reason. Compared with non-Hispanic Whites, Hispanics were at 1.44 odds of not accepting organ offers due to logistical reasons. These limited findings motivate further research into interventions that would improve candidates' readiness to accept organ offers and may benefit racial/ethnic minorities on the liver-transplantation wait list.
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