期刊
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
卷 14, 期 -, 页码 135-153出版社
ELSEVIER
DOI: 10.1016/j.csbj.2016.02.005
关键词
Nuclear magnetic resonance (NMR) spectroscopy; Metabolite identification; Molecular structure; Metabonomics; Metabolomics
Metabonomics/metabolomics is an important science for the understanding of biological systems and the prediction of their behaviour, through the profiling of metabolites. Two technologies are routinely used in order to analyse metabolite profiles in biological fluids: nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS), the latter typically with hyphenation to a chromatography system such as liquid chromatography (LC), in a configuration known as LC-MS. With both NMR and MS-based detection technologies, the identification of the metabolites in the biological sample remains a significant obstacle and bottleneck. This article provides guidance on methods for metabolite identification in biological fluids using NMR spectroscopy, and is illustrated with examples from recent studies on mice. (C) 2016 Dona et al. Published by Elsevier B.V. on behalf of the Research Network of Computational and Structural Biotechnology.
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