期刊
ACS MATERIALS LETTERS
卷 4, 期 1, 页码 159-164出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsmaterialslett.1c00570
关键词
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资金
- National Natural Science Foundation of China [21788102, 52003228]
- Research Grants Council of Hong Kong [N_HKUT609/19, 16305518, A-HKUST605/16, C6009-17G]
- Innovation and Technology Commission [ITC-CNERC14SC01, ITCPD/17-9]
A new deep-red AIE luminogen AlEgen was developed with high solid-state quantum yield, suitable for lipid droplet imaging and tracking with the advantage of two-photon imaging.
Lipid droplets (LDs) actively participate in many biological processes whose abnormality will result in different diseases; thus, it is vital to study the bioactivities of LDs. Red/near-infrared (NIR) fluorescent materials with aggregation-induced emission (AIE) characteristics are suitable for LD imaging and tracking because of their noninvasiveness, large Stokes shift, low photodamage, and excellent photostability. Meanwhile, two-photon imaging emerges with advantages of higher resolution and deeper penetration depth. In this work, a new acceptor core, benzothiadiazol-7-ylidene malononitrile (BSM), is proposed to construct a deep-red AIE luminogen (AlEgen) with a D-A structure. The AlEgen shows a high solid-state quantum yield of 13%, whose emission spectrum covers the visible and NIR I region. Furthermore, this molecule exhibits an excellent two-photon imaging performance and high specificity toward lipid droplets in all levels of biosubstances, including cells, tissues, and living zebrafish embryos, showing high potential for LD imaging and tracking in biomedical research.
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