4.6 Article

Dual-targeted lung cancer therapy via inhalation delivery of UCNP-siRNA-AS1411 nanocages

期刊

CANCER BIOLOGY & MEDICINE
卷 19, 期 7, 页码 1047-1060

出版社

CHINA ANTI-CANCER ASSOC
DOI: 10.20892/j.issn.2095-3941.2020.0416

关键词

Nanomaterials; VEGF siRNA; lung cancer; gene therapy; siRNA delivery

资金

  1. National Key Basic Research Program (973 Project) [2015CB931802, 2017FYA0205301]
  2. Special Fund for Science and Technology Innovation of Shanghai Jiao Tong University [YG2017MS70, YG2015MS62, AF0300179]
  3. Shanghai Municipal Bureau of Economy and Information Technology [XC-ZXSJ-02-2016-05]
  4. National Natural Scientific Foundation of China [8202010801, 81921002, 81225010, 81028009, 31170961]
  5. 863 Project of China [2014AA020700]
  6. Shanghai Science and Technology Fund [13NM1401500]

向作者/读者索取更多资源

The study developed a nanocage system based on up-conversion nanoparticles for targeted delivery of siRNA to tumor sites, which resulted in tumor suppression effects. The system protected siRNA from degradation while showing stable efficacy and longer survival times.
Objective: Although great progress has been made in the field of siRNA gene therapy, safe, efficient, and targeted delivery of siRNA are still major challenges in siRNA therapeutics. Methods: We developed an up-conversion nanoparticle-based nanocage system. This system protected the siRNA from being degraded by nucleases in organisms and selectively delivered the siRNAs to the tumor sites, due to modifications of targeted molecules on the surfaces of nanocages and local inhalation. Results: The siRNAs delivered by the up-conversion nanoparticle nanocages were protected from degradation in transit to the tumor sites, where they accumulated. Compared with the passive target and control groups, the up-conversion nanoparticles based on the nanocage system showed a tumor suppressive effect after approximately 3 weeks of treatment. Conclusions: The up-conversion nanoparticle nanocages efficiently delivered vascular endothelial growth factor siRNAs to tumor sites. Mice with lung tumors treated with tumors targeting up-conversion nanoparticle nanocages showed steady body weight changes, high tumor inhibition ratios, and longer survival times.

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