期刊
FRONTIERS IN ONCOLOGY
卷 6, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2016.00029
关键词
MRSI; P-31; relaxation time; 7 T; phosphodiester; breast; phospholipids
类别
Purpose: The identification of the phosphodiester (PDE) P-31 MR signals in the healthy human breast at ultra-high field. Methods: In vivo 3'P MRS measurements at 7 T of the PDE signals in the breast were performed investigating the chemical shifts, the transverse-and the longitudinal relaxation times. Chemical shifts and transverse relaxation times were compared with non-ambiguous PDE signals from the liver. Results: The chemical shifts of the PDE signals are shifted-0.5 ppm with respect to glycerophosphocholine (GPC) and glycerophosphoethanolamine (GPE), and the transverse and longitudinal relaxation times for these signals are a factor 3 to 4 shorter than expected for aqueous GPC and GPE. Conclusion: The available experimental evidence suggests that GPC and GPE are not the main source of the PDE signals measured in fibroglandular breast tissue at 7 T. These signals may predominantly originate from mobile phospholipids.
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