期刊
GENES & DISEASES
卷 9, 期 1, 页码 12-27出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.gendis.2021.08.004
关键词
Cancer; CCL5/CCR5; Infection; Therapy
资金
- Key R&D Project of Sichuan Province [2020YFS0553]
- Excellent Youth Foundation of Sichuan Scientific Committee Grant in China [2019JDJQ008]
- National Natural Science Foundation Regional Innovation and Development, China [U19A2003]
This review discusses the role of the CCL5/CCR5 axis in the pathological processes of different diseases, including inflammation, chronic diseases, cancers, and COVID-19. It also highlights the regulation of relevant signaling pathways and research and clinical trials for treating CCR5-related diseases.
To defense harmful stimuli or maintain the immune homeostasis, the body produces and recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among them, chemokines act as crucial regulators in defense systems. CCL5/CCR5 combination is known for facilitating inflammatory responses, as well as inducing the adhesion and migration of different T cell subsets in immune responses. In addition, recent studies have shown that the interaction between CCL5 and CCR5 is involved in various pathological processes including inflammation, chronic diseases, cancers as well as the infection of COVID-19. This review focuses on how CCL5/CCR5 axis participates in the pathological processes of different diseases and their relevant signaling pathways for the regulation of the axis. Moreover, we highlighted the gene therapy and chemotherapy studies for treating CCR5-related diseases, including the ongoing clinical trials. The barriers and perspectives for future application and translational research were also summarized. Copyright (C) 2021, Chongqing Medical University. Production and hosting by Elsevier B.V.
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