期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 11, 期 3, 页码 349-364出版社
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2015.11.123
关键词
Inorganic nanomaterials; Cancer therapy; Photothermal therapy; Multifunctional modification
资金
- National Natural Science Foundation of China [21401132]
- Research Project of Science and Technology of Department of Education of Liaoning Province [L2014377]
- Key Laboratory Program of Functional Inorganic Material Chemistry (Heilongjiang University), Ministry of Education
Novel nanomaterials and advanced nanotechnologies prompt the fast development of new protocols for biomedical application. The unique light-to-heat conversion property of nanoscale materials can be utilized to produce novel and effective therapeutics for cancer treatment. In particular, near-infrared (NIR) photothermal therapy (PTT) has gained popularity and very quickly developed in recent years due to minimally invasive treatments for patients. This review summarizes the current state-of-the-art in the development of inorganic nanocomposites for photothermal cancer therapy. The current states of the design, synthesis, the cellular uptake behavior, the cellular cytotoxicity and both in vivo and in vitro nanoparticle assisted photothermal treatments of inorganic photothermal therapy agents (PTA) are described. Finally, the perspective and challenges of PTT development are presented and some proposals are suggested for its further development and exploration. This summary should provide improved understanding of cancer treatment with photothermal nanomaterials and push nanoscience and nanotechnology one step at a time toward clinical applications. (C) 2016 The Authors. Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University.
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