期刊
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
卷 24, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12968-021-00819-z
关键词
Sex; Age; Cardiovascular magnetic resonance; Reference; Normal
资金
- Canadian Partnership Against Cancer (CPAC)
- Heart and Stroke Foundation of Canada (HSF-Canada)
- Canadian Institutes of Health Research (CIHR)
- Population Health Research Institute
- CIHR Foundation [FDN-143255, FDN-143313, FDN 154317]
- Canadian Partnership Against Cancer
- BC Cancer Foundation
- Genome Quebec
- Ontario Institute for Cancer Research
- Alberta Health
- Alberta Cancer Prevention Legacy Fund, Alberta Cancer Foundation
- Montreal Heart Institute Foundation
- Tier 1 Canada Research Chair in Ethnicity and Cardiovascular Disease
- Heart and Stroke Foundation Chair in Population Health
- Ministry of Research and Innovation of Ontario Investigator Award
- Hurvitz Brain Sciences Research Program
- Sunnybrook Research Institute
- Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto
- Laval University Chair of Research & Innovation in Cardiovascular Imaging
- Fonds de recherche du Quebec-Sante
- Swiss National Science Foundation (SNSF) [PP00P3_163892, PP00P3_190074]
- Olga Mayenfisch Foundation, Switzerland
- OPO Foundation, Switzerland
- Novartis Foundation, Switzerland
- Swissheart Foundation
- Helmut Horten Foundation, Switzerland
- University Hospital Zurich (USZ) Foundation
- Iten-Kohaut Foundation, Switzerland
- EMDO Foundation, Switzerland
- Swiss National Science Foundation (SNF) [PP00P3_190074, PP00P3_163892] Funding Source: Swiss National Science Foundation (SNF)
This study provides sex and age-specific normal reference values for cardiovascular magnetic resonance (CMR) parameters using an anatomically correct contouring method. These values are derived from the largest, multi-ethnic population free of cardiovascular disease (CVD) to date.
Background: Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters. Methods and results: Participants (n = 3206, 65% females; age 55.2 +/- 8.4 years for females and 55.1 +/- 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001). Conclusion: Using anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date.
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