期刊
ACS APPLIED BIO MATERIALS
卷 5, 期 1, 页码 295-304出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsabm.1c01086
关键词
silicon nanoparticles; tunable emission features; fluorescent mechanism; cell imaging; acid phosphatase
资金
- National Natural Science Foundation of China [22074154, 21822407]
- Gansu Youth Science and Technology Fund Project [20JR10RA051, 21JR1RA352]
- Gansu Innovation Group Project [20JR5RA573]
This study successfully synthesized green and red fluorescent silicon nanoparticles with different emission wavelengths using a facile one-step method, which exhibited good water solubility, salt tolerance, pH stability, and low cytotoxicity, making them suitable for applications such as multicolor cell imaging and multi-channel sensing.
Until now, the green and facile synthesis of multicolor fluorescent silicon nanoparticles (SiNPs) with favorable biocompatibility for cellular imaging and biosensors is still a challenge. Herein, a facile one-step room temperature method for preparing fluorescent SiNPs displayed different emission wavelengths was reported. Green and red fluorescent SiNPs (G-SiNPs and R-SiNPs) were synthesized by adjusting the concentration of the reducing agent 2,4-diaminophenol hydrochloride when the amount of N-[3-(trimethoxysilyl)-propyl]-ethylenediamine was consistent. Characterized by Fourier transform infrared spectroscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy, the results revealed that the G-SiNPs and R-SiNPs were assembled by polymerization of different building blocks, and the emission characteristics of these SiNPs were attributed to the difference in their structural composition and particle size. Interestingly, these fluorescent SiNPs exhibited excellent water solubility, salt tolerance, pH stability, photobleaching resistance, and low cytotoxicity, which facilitated multicolor cell imaging, and further led to these SiNPs were highly attractive in a variety of applications, such as multi-channel sensing and biological imaging. Furthermore, the R-SiNPs have shown the potential to detect acid phosphatase, which is a biomarker of prostate cancer.
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