期刊
REACTION CHEMISTRY & ENGINEERING
卷 1, 期 1, 页码 96-100出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5re00083a
关键词
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资金
- AstraZeneca
- EPSRC DTG
- University of Leeds
- EPSRC [EP/K039202/1] Funding Source: UKRI
- Austrian Science Fund (FWF) [J 3449] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [1603652, EP/K039202/1, 1232745] Funding Source: researchfish
An automated continuous reactor for the synthesis of organic compounds, which uses online mass spectrometry (MS) for reaction monitoring and product quantification, is presented. Quantitative and rapid MS monitoring was developed and calibrated using HPLC. The amidation of methyl nicotinate with aqueous MeNH2 was optimised using design of experiments and a self-optimisation algorithm approach to produce > 93% yield.
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