4.7 Article

Protein intake and outcome of critically ill patients: analysis of a large international database using piece-wise exponential additive mixed models

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The effect of higher versus lower protein delivery in critically ill patients: a systematic review and meta-analysis of randomized controlled trials

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Summary: This systematic review of randomized controlled trials found that higher daily protein delivery in critically ill patients did not lead to any significant improvement in clinical or patient-centered outcomes. Further larger and more definitive trials are needed to confirm the effect of muscle loss attenuation associated with higher protein delivery.

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