期刊
CELLS
卷 5, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/cells5010010
关键词
Hypoxia; NF-kappa B; IKK; HIF-1; PHDs; FIH; TAK; ubiquitin
类别
资金
- Cancer Research UK Senior Research Fellowship [C99667/A12918]
- Wellcome Trust PhD studentship
- Wellcome Trust [097945/B/11/Z]
- Cancer Research UK [12918] Funding Source: researchfish
As Nuclear Factor-kappa B (NF-kappa B) is a major transcription factor responding to cellular stress, it is perhaps not surprising that is activated by hypoxia, or decreased oxygen availability. However, how NF-kappa B becomes activated in hypoxia is still not completely understood. Several mechanisms have been proposed and this review will focus on the main findings highlighting the molecules that have been identified in the process of hypoxia induced NF-kappa B. In addition, we will discuss the role of NF-kappa B in the control of the cellular response to hypoxia.
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