期刊
CELLS
卷 5, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/cells5020022
关键词
NF-kappaB; RelB; post-translational modifications; cell motility; phosphorylation; ubiquitination; SUMOylation; NF-kappa B alternative pathway
类别
资金
- ANR
- ARC
- INCa
- Universite Paris Descartes, Sorbonne Paris Cite
The family of NF-kappa B transcription factors plays a key role in diverse biological processes, such as inflammatory and immune responses, cell survival and tumor development. Beyond the classical NF-kappa B activation pathway, a second NF-kappa B pathway has more recently been uncovered, the so-called alternative NF-kappa B activation pathway. It has been shown that this pathway mainly controls the activity of RelB, a member of the NF-kappa B family. Post-translational modifications, such as phosphorylation, acetylation, methylation, ubiquitination and SUMOylation, have recently emerged as a strategy for the fine-tuned regulation of NF-kappa B. Our review discusses recent progress in the understanding of RelB regulation by post-translational modifications and the associated functions in normal and pathological conditions.
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