期刊
ADVANCED INTELLIGENT SYSTEMS
卷 4, 期 4, 页码 -出版社
WILEY
DOI: 10.1002/aisy.202100189
关键词
artificial muscles; autonomous movements; nonequilibrium materials; protein soft robotics
资金
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [EXC-2193/1 - 390951807]
- BMBF [31A490, 031A550]
- Baden-Wurttemberg Stiftung Project BioUltraSpring
- Zentrum fur Biosystem Analyse (ZBSA)
- Freiburg Institute for Advanced Studies (FRIAS)
- Institute for Macromolecular Chemistry
- Institute for Micro System Engineering (IMTEK)
- BIOSS Centre for Biological Signalling Studies [EXC 294]
- Rectorate of the University of Freiburg
Complex multimaterial networks in the human body enable dynamic autonomous movements, which has sparked great interest in bioinspired mimicry of muscular systems in soft robotics and biomedicine. This article introduces an artificial protein muscle that exhibits rhythmic autonomous movements through chemically fueled pH oscillation reactions driven by nonequilibrium states.
Complex multimaterial networks of the human body, for example, muscles, enable dynamic autonomous movements. Bioinspired mimicry of muscular systems is of great interest in soft robotics and biomedicine. Currently a broad range of synthetic macromolecules and natural or modified biomacromolecules imitate muscular systems, but no protein muscles with mechanoactive protein components are realized. Biomimetic bio-based muscle systems allow to combine the potential of nature's high-performance proteins, for example, silk, resilin, elastin, or titin, with novel adaptive and functional properties and sustainable biotechnological production. While biological protein motors and muscles are powered by the hydrolysis of adenosine triphosphate, no synthetic bio-based muscles are described, operating autonomously using chemical energy to exert directional movements. Herein, an artificial protein muscle is introduced, exerting rhythmic autonomous movements via nonequilibrium states driven by chemically fueled pH oscillation reactions. Key to the design are recombinantly produced human matrix proteins selectively reengineered to respond to different stimuli. The results also show how directional movements can be independently triggered by changes in pH and temperature including a selective on-switch and a combination of nonequilibrium states enabling learning and oblivion-like material effects. This paves the road for the next generation of autonomous materials in pharmacy, soft robotics and living matter.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据