期刊
SLEEP
卷 39, 期 1, 页码 227-235出版社
OXFORD UNIV PRESS INC
DOI: 10.5665/sleep.5354
关键词
actigraphy; aging; magnetic resonance imaging; orbitofrontal cortex; sleep fragmentation
资金
- Canadian Institutes of Health Research [MSH136642, MOP125934, MMC112692]
- National Institutes of Health [R01AG17917, R01AG40039, R01AG043379, R01NS078009, R01AG34374, P20MD06886]
- Illinois Department of Public Health
- Rush Translational Science Consortium
Study Objectives: To test the hypothesis that greater sleep fragmentation is associated with regionally decreased cortical gray matter volume in older community-dwelling adults without cognitive impairment. Methods: We studied 141 community-dwelling older adults (median age 82.9; 73% female) without cognitive impairment or stroke, and not using sedative/hypnotic medications, participating in the Rush Memory and Aging Project. We quantified sleep fragmentation from 7 d of actigraphy using the metric kRA and related this to total cortical gray matter volume, and regional gray matter volume in 34 cortical regions quantified by automated segmentation of magnetic resonance imaging data. We determined statistical significance and accounted for multiple comparisons by empirically estimating the false discovery rate by permutation. Results: Lower total cortical gray matter volume was associated with higher sleep fragmentation (coefficient +0.23, standard error [SE] 0.11, P = 0.037). Lower gray matter volumes in four cortical regions were accompanied by higher sleep fragmentation with a false discovery rate <0.05: the left (coefficient +0.36, SE 0.10, P = 2.7 x 10(-4)) and right (coefficient +0.31, SE 0.10, P = 4.0 x 10(-3)) lateral orbitofrontal cortices, and the adjacent left (coefficient +0.31, SE 0.10, 5.4 x 10(-4)) and right (coefficient +0.39, SE 0.10, P = 1.2 x 10(-4)) inferior frontal gyri pars orbitalis. These associations were unchanged after accounting for age, sex, education, depression, cognitive function, and a number of medical comorbidities. Conclusions: Lower cortical gray matter volume in the lateral orbitofrontal cortex and inferior frontal gyrus pars orbitalis is associated with greater sleep fragmentation in older community-dwelling adults. Further work is needed to clarify whether this is a consequence of or contributor to sleep fragmentation. Commentary: A commentary on this article appears in this issue on page 15.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据