期刊
AGING-US
卷 14, 期 1, 页码 253-271出版社
IMPACT JOURNALS LLC
关键词
OA; subchondral bone; osteopontin; bone turnover; remodeling
资金
- National Natural Science Foundation of China [81902268]
- Natural Science Foundation of Guangdong Province [2020A1515010207]
- China Postdoctoral Science Foundation [2019TQ0385, 2019M663264]
- medical and health projects of Shantou science and technology plan [190923175260442, 190915165269567]
This study investigated the role of osteopontin (OPN) in the subchondral bone changes of osteoarthritis (OA) and found that increased expression of OPN accelerates the turnover and remodeling of subchondral bone and mediates articular cartilage degeneration induced by subchondral bone metabolism. Additionally, inhibition of the PI3K/AKT signaling pathway was found to inhibit OPN-mediated subchondral bone remodeling and cartilage degeneration.
Osteopontin (OPN) has been proved to be closely related to the pathogenesis of osteoarthritis (OA), but the role of OPN in the pathogenesis of OA has not been fully clarified. Current studies on OPN in OA mostly focus on articular cartilage, synovial membrane and articular fluid, while ignoring its role in OA subchondral bone turnover and remodeling. In this study, we used a destabilization OA mouse model to investigate the role of OPN in OA subchondral bone changes. Our results indicate that increased expression of OPN accelerates the turnover and remodeling of OA subchondral bone, promotes the formation of h-type vessels in subchondral bone, and mediates articular cartilage degeneration induced by subchondral bone metabolism. In addition, our results confirmed that inhibition of PI3K/AKT signaling pathway inhibits OPN-mediated OA subchondral bone remodeling and cartilage degeneration. This study revealed the role and mechanism of OPN in OA subchondral bone, which is of great significance for exploring specific biological indicators for early diagnosis of OA and monitoring disease progression, as well as for developing drugs to regulate the metabolism and turnover of subchondral bone and alleviate the subchondral bone sclerosis of OA.
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