期刊
ACTA NEUROPATHOLOGICA COMMUNICATIONS
卷 4, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s40478-016-0321-8
关键词
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资金
- Cancer Research UK Funding Source: Medline
- Medical Research Council [MR/M000125/1] Funding Source: Medline
- Department of Health [NIHR-CS-012-002] Funding Source: Medline
- MRC [MR/M000125/1] Funding Source: UKRI
- Cancer Research UK [S_1731] Funding Source: researchfish
- Children with Cancer UK [15-190] Funding Source: researchfish
- Great Ormond Street Hospital Childrens Charity [W1097, W1055] Funding Source: researchfish
- Medical Research Council [MR/M000125/1] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0513-10046, NIHR-CS-012-002] Funding Source: researchfish
- The Brain Tumour Charity [8/152, 16/193] Funding Source: researchfish
Tissue invasion and infiltration by brain tumours poses a clinical challenge, with destruction of structures leading to morbidity. We assessed whether micro-CT could be used to map tumour invasion in adamantinomatous craniopharyngioma (ACP), and whether it could delineate ACPs and their intrinsic components from surrounding tissue. Three anonymised archival frozen ACP samples were fixed, iodinated and imaged using a micro-CT scanner prior to the use of standard histological processing and immunohistochemical techniques. We demonstrate that micro-CT imaging can non-destructively give detailed 3D structural information of tumours in volumes with isotropic voxel sizes of 4-6 microns, which can be correlated with traditional histology and immunohistochemistry. Such information complements classical histology by facilitating virtual slicing of the tissue in any plane and providing unique detail of the three dimensional relationships of tissue compartments.
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